IFNL3 polymorphisms and HCV infection in patients with beta thalassemia
نویسندگان
چکیده
منابع مشابه
IFNL3 polymorphisms and HCV infection in patients with beta thalassemia.
UNLABELLED BACKGROUND AND RATIONALE FOR THE STUDY: Genome-wide association studies have identified host genetic variation to be critical for spontaneous clearance and treatment response in patients infected with hepatitis C virus. Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous clearance of HCV, the response to interferon and the progression of liver fibrosis, was a...
متن کاملIFNL3 polimorphisms and HCV infection in patients with beta thalassemia
Background and relationale for the study. Genome-wide association studies have identified host genetic variation to be critical for spontaneous clearance and treatment response in patients infected with hepatitis C virus. Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous clearance of HCV, the response to interferon and the progression of liver fibrosis, was also demon...
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Background: β-thalassemia as a hereditary disease is defined as defective synthesis of β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of β-thalassemia. Single nucleotide polymorphisms (SNPs) within the promoter region or other regulatory sequences ...
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background: hepatitis c virus (hcv) is the major cause of post-transfusion hepatitis infection (pth). patients with thalassemia major are at high risk of hepatitis c due to the blood transfusion from donors infected by hcv. the aim of this study was to detect the prevalence of anti-hcv antibodies and risk factors in multitransfused thalassemic patients in isfahan-iran to establish more preventi...
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background: β-thalassemia as a hereditary disease is defined as defective synthesis of β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of β-thalassemia. single nucleotide polymorphisms (snps) within the promoter region or other regulatory sequences ...
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ژورنال
عنوان ژورنال: Annals of Hepatology
سال: 2015
ISSN: 1665-2681
DOI: 10.1016/s1665-2681(19)31279-7